id author title date pages extension mime words sentences flesch summary cache txt work_ieoyxmjspva6fg56gux2jyhxzq M. Fu Evidence That Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) on 1q21 is a Type 2 Diabetes Susceptibility Gene in the Old Order Amish 2007.0 6 .pdf application/pdf 4888 459 66 the genotype frequencies of subjects with type 2 diabetes for linkage of type 2 diabetes and impaired glucose tolerance (IGT) to chromosome 1q21-q24 (logarithm of odds 52 SNPs spanning the entire ARHGEF11 gene were significantly associated with type 2 diabetes or type 2 diabetes/ 1. Association analysis of 52 SNPs in ARHGEF11 with type 2 diabetes cases (DM; n � 145) and combined type 2 diabetes/IGT cases (DMIGT; associated with a significantly higher risk of type 2 diabetes/IGT (P � 0.010), while the AGAAGCTTA haplotype ARHGEF11 SNPs significantly associated with type 2 diabetes and type 2 diabetes/IGT in the Amish within ARHGEF11 influences risk of type 2 diabetes/IGT in Haplotype frequencies were estimated with Haploscore for the nine positively associated ARHGEF11 SNPs by case-control analysis and Sakul H, Wagner MJ, Burns DK, Shuldiner AR: Genome-wide and finemapping linkage studies of type 2 diabetes and glucose traits in the Old type 2 diabetes on chromosome 1q, are nominally associated with insulin ./cache/work_ieoyxmjspva6fg56gux2jyhxzq.pdf ./txt/work_ieoyxmjspva6fg56gux2jyhxzq.txt