id author title date pages extension mime words sentences flesch summary cache txt work_hro7jst6azctnba3jo7albxzem Yulia Shifrin Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature 2015.0 13 .pdf application/pdf 10311 1451 66 Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature Maternal-pup interaction disturbances induce longlasting changes in the newborn rat pulmonary vasculature. fostered rats exhibited reduced pulmonary arterial endothelium-dependent relaxation secondary to downregulation of tissue endothelial nitric These changes were associated with neonatal onset-increased ANG II receptor type 1 expression, PV remodeling, and right In hypothesizing that maternal cross-fostering promotes neonatal pulmonary vasomotor changes via RAAS, we comparatively evaluated control and fostered rat pups in the immediate species (ROS) scavenger, reduced the fostered adult animals' U46619-induced dose response to a level comparable Given the abnormal endothelium-dependent pulmonary arterial relaxation response of 14-day-old fostered pups, we To test whether cross-fostering-induced eNOS uncoupling was related to BH4 deficiency, we determined the lung tissue BH4/BH2 content lungs when compared with control rat values (Fig. 13), suggesting that this pathway plays a role in fostering-induced ROS ./cache/work_hro7jst6azctnba3jo7albxzem.pdf ./txt/work_hro7jst6azctnba3jo7albxzem.txt