id author title date pages extension mime words sentences flesch summary cache txt work_hknrajcmqnexridbeycywk54gq A. Charlotte P. Sewing Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α 2012.0 13 .pdf application/pdf 9794 1003 58 Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-�. Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-�. published May 11, 2012; doi:10.1152/ajplung.00072.2012.—Bleomycin-induced lung injury is characterized in the neonatal rat by inflammation, arrested lung growth, and pulmonary hypertension (PHT), as prevented bleomycin-induced PHT without decreasing tissue macrophages and, similar to CO2, had no effect on arrested alveolar Neither tissue macrophages nor TNF-� appeared to contribute to arrested lung development induced by bleomycin. preventive effects on bleomycin-induced PHT without affecting lung growth, arrested alveolarization, or vascular Effects of TNF-� inhibition on bleomycin-induced pulmonary hypertension, macrophage influx, and abnormal distal contrast, treatment with etanercept had no effect on bleomycininduced macrophage influx (Fig. 4C), indicating that upregulated TNF-� signaling does not contribute to increased numbers of activated tissue macrophages in the bleomycin-exposed TNF-� inhibition prevents bleomycin-induced pulmonary hypertension without affecting tissue macrophage number. ./cache/work_hknrajcmqnexridbeycywk54gq.pdf ./txt/work_hknrajcmqnexridbeycywk54gq.txt