id author title date pages extension mime words sentences flesch summary cache txt work_gs2gvysgvvfdbcznyzllri2yye Robert Wojciechowski Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36 2009.0 9 .pdf application/pdf 7287 700 51 Purpose: A previous genome-wide study in Orthodox Ashkenazi Jewish pedigrees showed significant linkage of ocular Orthodox Ashkenazi Jewish (ASHK) and Old Order Amish (OOA) families to confirm linkage and narrow the candidate Multipoint variance components (VC) and regression-based (REG) linkage analyses were carried out separately in OOA Results: Evidence of linkage of refractive error was found in both OOA (VC LOD=3.45, REG LOD=3.38 at ~59 cM) Conclusion: In a fine-mapping linkage study of OOA and ASHK families, we have confirmed linkage of refractive error Finally, genetic linkage studies generally lack the statistical The first genetic linkage studies of refractive phenotypes findings in a fine-mapping linkage study in OOA families, and families were selected for linkage studies of myopia and thus linkage analyses for ASHK and OOA families are presented In a genomewide linkage study of ASHK Jewish families, variations of refractive error in both OOA and ASHK families. ./cache/work_gs2gvysgvvfdbcznyzllri2yye.pdf ./txt/work_gs2gvysgvvfdbcznyzllri2yye.txt