id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_gigjzrqgcng45ike54rkflikbe	Liping Hou	A population-specific reference panel empowers genetic studies of Anabaptist populations	2017.0	9	.pdf	application/pdf	6269	509	55	report the Anabaptist Genome Reference Panel (AGRP), the first whole-genome catalogue of variants Previous studies in population isolates have successfully identified genes and variants associated with Mendelian5 and complex traits4, 6. Anabaptists represent a genetic isolate comprising several groups, including Amish and Mennonites, whose Since whole genome sequencing (WGS) is still expensive in large samples, many study designs rely on genotype imputation of unsequenced individuals. population-specific imputation reference panel drawn from people of Anabaptist ancestry. population structure and allele frequency spectra represented by the AGRP and estimate the impact of this reference panel on the imputation accuracy of variants across the full range of allele frequencies. The merged AGRP and 1000G reference panel provided the highest imputation accuracy across all allele To investigate one measure of genetic diversity, we compared the total length of the genome shared homozygous by descent (HBD) among individuals within the AGRP to that shared between AGRP and Europeans in 	./cache/work_gigjzrqgcng45ike54rkflikbe.pdf	./txt/work_gigjzrqgcng45ike54rkflikbe.txt