id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_gdaxyv4qejhy3l7nfgdumzlvfy	Pooja Malhotra	Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation	2014.0	9	.pdf	application/pdf	7486	670	63	Background: Cholesterol transporter NPC1L1 is expressed in small intestine but not in colon. Results: DNA in the mouse NPC1L1 gene is hypermethylated in colon as compared with small intestine. Conclusion: DNA hypermethylation may be responsible for silencing NPC1L1 expression in the colon. Significance: Altering DNA methylation may represent a novel mechanism to modulate NPC1L1 expression and cholesterol that DNA methylation in the promoter region of the NPC1L1 gene These observations indicated that DNA methylation might play a role in suppressing the colonic expression of genes that are usually DNA methylation in suppressing the expression of NPC1L1 DNA methylation of mouse NPC1L1 promoter in the small intestine and colon. To further investigate the effect of inhibiting DNA methylation on NPC1L1 expression in HuTu-80 cells, we attenuated Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation* Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation*	./cache/work_gdaxyv4qejhy3l7nfgdumzlvfy.pdf	./txt/work_gdaxyv4qejhy3l7nfgdumzlvfy.txt