id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_gctsgoci5ras7cfi4eb5mxukoi	Gissette Reyes-Soffer	Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism	2019.0	10	.pdf	application/pdf	10391	1009	70	lipoprotein metabolism was later expanded by studies in perfused rat livers demonstrating that apo CIII inhibits uptake of that absence of apo CIII resulted in a dramatic increase in lipolysis of VLDL (very-low-density lipoprotein)-TG.7 Studies © 2018 American Heart Association, Inc. Objective—Apo (apolipoprotein) CIII inhibits lipoprotein lipase (LpL)-mediated lipolysis of VLDL (very-low-density rates of VLDL-TG and apoB100 in VLDL, IDL (intermediate-density lipoprotein), LDL, apo CIII, and apo CII were IDL-, and LDL-apoB100 and plasma amino acids, and 1 tracer, glycerol, in VLDL-TG) is chosen for the final model. effects of reduced apo CIII levels on the partitioning of VLDLapoB100 flux between conversion of VLDL to LDL and direct These data indicate that, in individuals heterozygous for loss of function of APOC3, who have normal levels of lipoprotein lipase, reduced levels of apo CIII in plasma significantly affect the lipolytic but not the hepatic uptake pathways for metabolism of VLDL.	./cache/work_gctsgoci5ras7cfi4eb5mxukoi.pdf	./txt/work_gctsgoci5ras7cfi4eb5mxukoi.txt