id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ffabvo5cxbfevk6woubxxv23gu	J. Ott	Predicting the range of linkage disequilibrium	2000.0	2	.pdf	application/pdf	1597	262	79	mapping of a disease gene is to initially a disease gene than does linkage. markers (1) to localize disease genes by impact on such association mapping studies. Isolated populations often are considered advantageous for association mapping (7) but some examples have been found in which the extent of linkage disequilibrium is the same in small isolated strong disequilibrium in small populations small, whether disequilibrium will be extensive around disease loci. versus distance, d, between loci on a haplotype. two clusters of haplotypes, one corresponding to low and one with high association. that disequilibrium and physical distance Sample data on linkage disequilibrium (r) and distance (d, in kb) between disease genes and nearby SNP markers Disease gene Population r d x12 shows the observed association values between disease and closest marker loci at of this small sample, it appears quite convincing that increasing population isolation is more or less correlated with increasing association.	./cache/work_ffabvo5cxbfevk6woubxxv23gu.pdf	./txt/work_ffabvo5cxbfevk6woubxxv23gu.txt