id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_dbbvwgi6and2fokqess5tojy2u	Monica Cubillos-Rojas	The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination	2016.0	24	.pdf	application/pdf	11730	1019	57	Keywords: ubiquitin, p53, Angelman syndrome, Purkinje cells, behavioural analysis, Pathology Section determined in the testes, brain, heart and kidney of Herc2530 mice and detected by X-gal staining. altered in Herc2+/530 mice during the time studied (Figure Figure 3: p53 inactivation did not rescue the lethality of Herc2530/530 homozygous mice. c. The analysis of mice from a cross of double heterozygous Herc2+/530 p53+/animals. mRNA levels was observed in Herc2+/530 mice (Figure 5B). Figure 6: A homozygous mutation in human HERC2 that causes an Angelman-like syndrome reduces the activity of Figure 7: Impaired motor coordination in Herc2+/530 mice. lysosomes observed in Herc2+/530 Purkinje cells (Figure Figure 8: Purkinje cells loss in Herc2+/530 mice. the Herc2+/530 cerebellum indicative of Purkinje cell loss are observed (arrows and arrowheads, in (D-F). Figure 10: Purkinje cell degeneration in Herc2+/530 mice. observed in Purkinje cells of Herc2+/530 mice.	./cache/work_dbbvwgi6and2fokqess5tojy2u.pdf	./txt/work_dbbvwgi6and2fokqess5tojy2u.txt