id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_av7risa7l5fcpp4ydcvirz6lpi	Patrick F McArdle	Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study	2008.0	11	.pdf	application/pdf	6129	739	46	"Nicotinic acetylcholine receptor subunit variants are associated with blood by genotyping blood pressure-associated variants (n = 5) in a replication sample of 1,759 individuals acetylcholine receptor, particularly the gamma subunit, in systolic blood pressure regulation. Associated variants were genotyped in an outbred Caucasian population from the Framingham Heart Study as a replication sample. We provide the first evidence that a common genetic variant in CHRNG is associated with systolic blood pressure. Simple linear regression was used to test for the association between genotype and blood pressure in the Framingham sample. only SNP showing significant association with blood pressure in the Framingham sample. Evidence from animal models supports the role of the nicotinic acetylcholine receptor in blood pressure regulation blood pressure levels maintain relatively constant numTable 1: Sample characteristics for the AFDS, FHS, and the HAPI Heart Study. Table 2: Association analysis of polymorphisms in CHRNA1, CHRND and CHRNG with blood pressure in the AFDS.	./cache/work_av7risa7l5fcpp4ydcvirz6lpi.pdf	./txt/work_av7risa7l5fcpp4ydcvirz6lpi.txt