id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_5ryulh2dabcyxcfivowbc2mkri	John B Vincent	An Unstable Trinucleotide-Repeat Region on Chromosome 13 Implicated in Spinocerebellar Ataxia: A Common Expansion Locus	2000.0	11	.pdf	application/pdf	7108	604	64	Larger CAG/CTG trinucleotide-repeat tracts in individuals affected with schizophrenia (SCZ) and bipolar affective disorder (BPAD) in comparison with control individuals have previously been reported, implying a possible etiological role for trinucleotide repeats in these diseases. have recently been cloned, and studies indicate that the majority of individuals with large repeats as detected by Figure 1 Southern blot of EcoRI-digested genomic DNA hybridized with a large (1.5–3-Kb), nonspecific CAG/CTG repeat probe. Figure 2 RED on primary lgt10 clones (a–j) picked from genomic library (screened with CAG/CTG probe) generated from individual A7 (RED from genomic DNA: lane number). Southern hybridization, followed by stringent washing, of EcoRI-digested genomic DNA with a large, nonspecific CAG/CTG repeat probe (1.5–3 Kb) revealed a lgt10/genomic library, which was then screened for repeat containing clones by use of the large CAG/CTG Parikh SV, Vincent JB, Kennedy JL (1999) Clinical characteristics of bipolar disorder subjects with large CAG/CTG repeat DNA.	./cache/work_5ryulh2dabcyxcfivowbc2mkri.pdf	./txt/work_5ryulh2dabcyxcfivowbc2mkri.txt