id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_5m7y6bxw3fdz7ekk4or6svi5nm	Amish A Naik	Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing	2009.0	14	.pdf	application/pdf	10339	866	60	a decreased rate of chondrogenesis, decreased bone formation, reduced callus vascularization, delayed remodeling, and altered expression of genes involved in repair and remodeling. and bone formation to levels observed in young mice, suggesting that the expression of COX-2 during the mechanisms involved.(1–3) The rate of bone repair is progressively reduced with aging from the pediatric population to the elderly.(4,5) Delayed healing results in an increased duration of immobilization, increases the risk of of fracture healing and the pattern of gene expression between young and aged animals. Our findings established reduced COX-2 expression in fractures in aged mice. harvested from young mice BMP-2, expression was elevated early during the endochondral phase of fracture repair, with peak expressions present between 5 and 10 days, 3. Fracture in aged mice have altered patterns of gene expression during the chondrogenesis, bone formation, and remodeling Peak expression of col2a1, COX-2, RANKL, and OPG occur in fractures in young mice	./cache/work_5m7y6bxw3fdz7ekk4or6svi5nm.pdf	./txt/work_5m7y6bxw3fdz7ekk4or6svi5nm.txt