id author title date pages extension mime words sentences flesch summary cache txt work_273kt2pob5babnlxutypj5z4ri Karl W. Broman Long Homozygous Chromosomal Segments in Reference Families from the Centre d'Étude du Polymorphisme Humain 1999.0 8 .pdf application/pdf 5872 545 63 Long Homozygous Chromosomal Segments in Reference Families from the (CEPH), we identified numerous long chromosomal segments of marker homozygosity in many CEPH individuals. progeny in family 884 were homozygous over 5–16 segments with average length 11 cM. In the process, we identified several long segments of noninformative markers in family 884, caused In forming the LOD score, we assumed that the markers were in both linkage and Hardy-Weinberg equilibrium, and we used a simple model for genotyping errors All individuals in family 884 had at least one homozygous segment with a LOD score 14.67. The 14 progeny in family 102 showed 4–12 homozygous segments with average length 18.5 cM and covering, on average, 155 cM (4.4% of the autosomal genome) (table 5). 2.2% of the autosomal genome, indicating a close relationship between her parents; 19 of the other individuals in these families had quite small homozygous segments. ./cache/work_273kt2pob5babnlxutypj5z4ri.pdf ./txt/work_273kt2pob5babnlxutypj5z4ri.txt