This article explores implementation science with a focus on the strategies leaders use to address organizational challenges. Part of a larger study, we employed a qualitative multiple case study design of 20 charter schools to contribute to an evidence base about how leadership at the charter school and charter management organization levels can influence their school communities regarding commitment to students with disabilities. From our exploratory research, key themes emerged that align with effective leadership strategies for implementation demonstrating the positive influence of leaders who prioritize students with disabilities by maintaining a clear vision and strong sense of purpose, creating a safe environment where diversity of perspectives is encouraged, and making sure all voices are heard and valued. Public schools across the nation can leverage lessons learned from the charter sector, as leaders work to ensure that their school practices and policies support success for students with disabilities. By ensuring that school leaders are trained and supported to use effective leadership strategies, policymakers, and schools of higher education can influence the adoption and advancement of innovative and effective practices.