Mayland Chang receives NFL Charities grant to study traumatic brain injury therapies | News | Notre Dame News | University of Notre Dame Skip To Content Skip To Navigation Skip To Search University of Notre Dame Notre Dame News Experts ND in the News Subscribe About Us Home Contact Search Menu Home › News › Mayland Chang receives NFL Charities grant to study traumatic brain injury therapies Mayland Chang receives NFL Charities grant to study traumatic brain injury therapies Published: December 22, 2010 Author: Marissa Gebhard Mayland Chang, a faculty member in the Department of Chemistry and Biochemistry at the University of Notre Dame, has received a grant from NFL Charities to design and develop therapeutics for the treatment of traumatic brain injury. NFL Charities, the charitable foundation of the National Football League owners, has awarded more than $1.6 million in grants to support sports-related medical research at 16 organizations, including Notre Dame. Of these grants, $988,224 will go to research groups studying concussion prevention and treatment. Traumatic brain injury (TBI) is one of the leading causes of death and disability in the industrialized world. Concussions are a common concern in sports, with 300,000 reported concussions in the United States occurring while playing sports and with football accounting for the highest proportion of concussions in high school athletes. Concussions result from a blow to the head that produces a cascade of neurological events, resulting in reduced blood flow to the brain, neuronal cell injury and death. A contributing factor to these pathological processes is the activation of matrix metalloproteinases (MMPs), particularly gelatinases (MMP-2 and MMP-9). “Research in the field presently lacks the ability to rescue brain cells after each concussion or any damage to the brain,” Chang says. “If a medication could be given after such a damage that rescues the brain cells destined to die, that would move the field forward in treatment of TBI significantly. We are proposing ground-breaking research that has the potential for the development of such a treatment for TBI.” Chang is working with Zezong Gu, assistant professor of neuroanatomy and neuroscience at the University of Missouri, to design water-soluble gelatinase inhibitors. They hypothesize that selective mechanism-based inhibition of MMP-9 activity prevents brain proteolysis of basal membrane components and rescues neurons from the consequences of TBI. They plan to design a water-soluble gelatinase inhibitor variant of SB-3CT that would advance to preclinical development and clinical trials for the treatment of TBI. The highly selective mechanism-based gelatinase inhibitor SB-3CT is effective in preventing proteolysis of basal membrane laminin and can rescue neurons from ischemia-induced brain injury and apoptosis. Most importantly, significant therapeutic activity of SB-3CT is seen up to 6 hours after initial brain damage. Mechanism-based gelatinase inhibition could protect the neurovascular integrity of the brain from TBI by blocking degradation of the basal membrane components such as laminin, exerting anti-apoptotic effects on neurons, reducing brain edema, and preventing apoptosis. Therefore, treatment with selective mechanism-based gelatinase inhibitors holds great promise for minimizing neuron damage and brain swelling associated with TBI. NFL Commissioner Roger Goodell, president of the NFL Charities Board, says: “We are proud to support sports-related medical research proposals through NFL Charities Medical Research Grants. These grants will help to address risk factors for football players and all athletes, and make the game safer.” The NFL has supported sports-related medical research for decades through NFL Charities medical research grants. Since 2000, NFL Charities has funded grants for studies on brain injury, ACL injury prevention and heat stress risks. Other studies funded this year include research on the association between football exposure and dementia in retired football players; the dynamic heart rate behavior of NFL athletes; the prevalence, distribution and fate of MRSA on synthetic turf grass systems; concussion surveillance among a large national sample of middle school football players; the role of cervical spine in football-related concussion; and an integrated neuroimaging study for diagnosing and monitoring mild TBI in football players. Contact: Mayland Chang, Department of Chemistry and Biochemistry, 574-631-2965, mchang@nd.ed Posted In: Research Home Experts ND in the News Subscribe About Us Related October 05, 2022 Astrophysicists find evidence for the presence of the first stars October 04, 2022 NIH awards $4 million grant to psychologists researching suicide prevention September 29, 2022 Notre Dame, Ukrainian Catholic University launch three new research grants September 27, 2022 Notre Dame, Trinity College Dublin engineers join to advance novel treatment for cystic fibrosis September 22, 2022 Climate-prepared countries are losing ground, latest ND-GAIN index shows For the Media Contact Office of Public Affairs and Communications Notre Dame News 500 Grace Hall Notre Dame, IN 46556 USA Facebook Twitter Instagram YouTube Pinterest © 2022 University of Notre Dame Search Mobile App News Events Visit Accessibility Facebook Twitter Instagram YouTube LinkedIn